SMOX

Across TCGA pan-cancer cohorts, SMOX RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of SMOX’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SMOX RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SMOX is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, HNSC, and KIRC are the cancer types where SMOX tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMOX RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+2.601	<.001	12	view →
HNSC	Male	III,IV	+2.198	<.001	12	view →
KIRC	Female	All	+1.280	<.001	11	view →
LIHC	Male	III,IV	+2.080	<.001	8	view →
LUSC	Male	II,III,IV	+2.019	<.001	8	view →
LUAD	Male	II,III,IV	+1.652	<.001	8	view →
KICH	All	II,III,IV	−1.529	<.001	8	view →
READ	Male	All	+2.590	<.001	7	view →
STAD	All	II,III,IV	+1.180	<.001	7	view →
KIRP	All	All	+0.937	<.001	7	view →
CHOL	Male	All	+3.570	<.001	5	view →
THCA	Female	III,IV	+0.848	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

SMOX–COAD

Open the COAD breakdown →