SMOX

Across TCGA cell cohorts, SMOX mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SMOX-associated genes across cancer lineages are OR1C1, SLC35G3, and PZP. Each is linked with SMOX in more than 1 cancer types. Because this analysis shows association rather than direction, both SMOX-to-partner and partner-to-SMOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1C1 grouped by SMOX-low versus SMOX-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMOX→partner) and Y-score (partner→SMOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR1C1 →	+0.038	+3.523	<.001	.008	3	2
URINARY_TRACT	SLC35G3 →	+0.006	+5.087	<.001	.004	3	2
LUNG_SCLC	PZP →	+0.055	+4.459	<.001	.001	3	1
LUNG_SCLC	LYZL2 →	+0.016	+4.058	<.001	.007	3	1
LUNG_SCLC	ACSM2A →	+0.022	+3.523	<.001	.008	3	1
LUNG_SCLC	KRTAP19-2 →	+0.102	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

OR1C1 by SMOX expression — LUNG_SCLC

Explore this box plot interactively →