SMOX

Across TCGA cell cohorts, SMOX mutation is significantly associated with the mutation status of many other genes, with 4,957 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMOX-associated genes across cancer lineages are IGF1R, ATP1A4, and ZNF418. Each is linked with SMOX in more than 4 cancer types. Because this analysis shows association rather than direction, both SMOX-to-partner and partner-to-SMOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGF1R grouped by SMOX-low versus SMOX-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMOX→partner) and Y-score (partner→SMOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IGF1R →	+4.297	+4.857	.009	.009	1	5
STOMACH	ATP1A4 →	+4.807	+4.807	.008	.008	1	4
STOMACH	ZNF418 →	+4.807	+4.807	.008	.008	1	4
OVARY	KDM4C →	+4.930	+3.977	.001	.001	1	4
BLOOD_Leukemia	ZNF236 →	+2.584	+3.640	.003	.003	1	4
BLOOD_Leukemia	FHOD3 →	+3.063	+3.498	.006	.006	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,957 associations by consensus.

IGF1R by SMOX expression — BREAST

Explore this box plot interactively →