SMIM2

Across TCGA patient cohorts, SMIM2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMIM2-associated genes across cancer lineages are NUDT4B, MIR4710, and IGHV1OR15-4. Each is linked with SMIM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMIM2-to-partner and partner-to-SMIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUDT4B grouped by SMIM2-low versus SMIM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM2→partner) and Y-score (partner→SMIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUDT4B →	+0.162	+5.621	<.001	.004	3	1
UCEC	MIR4710 →	+1.583	+5.031	<.001	.009	3	1
UCEC	IGHV1OR15-4 →	+0.359	+5.937	<.001	.002	3	1
UCEC	RNY4P27 →	+0.522	+6.453	<.001	.001	3	1
UCEC	MT-TA →	+0.634	+5.484	<.001	.005	3	1
UCEC	MLLT10P2 →	+0.487	+5.242	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

NUDT4B by SMIM2 expression — UCEC

Explore this box plot interactively →