SMIM17

Across TCGA patient cohorts, SMIM17 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMIM17-associated genes across cancer lineages are RNU6-737P, RNU6-1228P, and RNA5SP212. Each is linked with SMIM17 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMIM17-to-partner and partner-to-SMIM17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-737P grouped by SMIM17-low versus SMIM17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM17→partner) and Y-score (partner→SMIM17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-737P →	+0.254	+4.400	<.001	.006	3	1
UCEC	RNU6-1228P →	+0.291	+4.727	<.001	.003	3	1
UCEC	RNA5SP212 →	+0.964	+3.771	<.001	.003	3	1
UCEC	ATF4P1 →	+0.125	+4.132	<.001	<.001	3	1
UCEC	MIR1251 →	+0.291	+5.148	<.001	.002	3	1
UCEC	DIP2A-IT1 →	+0.470	+3.792	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

RNU6-737P by SMIM17 expression — UCEC

Explore this box plot interactively →