SMIM14

Across TCGA patient cohorts, SMIM14 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMIM14-associated genes across cancer lineages are p62 Lck ligand, STAT3_pY705, and Tuberin. Each is linked with SMIM14 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMIM14-to-partner and partner-to-SMIM14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by SMIM14-low versus SMIM14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM14→partner) and Y-score (partner→SMIM14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.723	+3.331	<.001	.005	3	1
UCEC	STAT3_pY705 →	-0.461	-2.990	<.001	.036	3	1
UCEC	Tuberin →	+0.407	+3.321	.003	.010	3	1
UCEC	VHL →	-1.374	-3.169	<.001	.019	3	1
UCEC	eIF4E →	+0.276	+3.000	.012	.036	2	1
UCEC	eIF4G →	+0.374	+3.321	.021	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

p62 Lck ligand by SMIM14 expression — UCEC

Explore this box plot interactively →