SMIM14

Across TCGA pan-cancer cohorts, SMIM14 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of SMIM14’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SMIM14 RNA is repressed in tumor relative to normal tissue. In most cancer types SMIM14 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and LUSC are the cancer types where SMIM14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMIM14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−2.072	<.001	11	view →
KICH	Female	All	−1.464	<.001	11	view →
LUSC	Male	III,IV	−1.732	<.001	8	view →
READ	Male	All	−2.083	<.001	7	view →
KIRC	All	All	−0.340	<.001	7	view →
BLCA	All	All	−0.732	.002	6	view →
BRCA	All	II,III,IV	+0.473	<.001	6	view →
LIHC	Female	All	−0.721	<.001	4	view →
HNSC	Male	II,III,IV	−0.518	.020	4	view →
CHOL	All	All	−1.312	<.001	2	view →
UCEC	All	All	−0.778	.002	2	view →
ESCA	Male	All	−0.714	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

SMIM14–COAD

Open the COAD breakdown →