SMIM14

Across TCGA pan-cancer cohorts, SMIM14 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SMIM14 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SMIM14 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SMIM14 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UCEC are the cancer types where SMIM14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.827	0.707	<.001	95	view →
SKCM	DFS	Median	All	0.682	0.551	<.001	79	view →
UCEC	OS	Quartile	All	0.944	0.820	<.001	74	view →
KIRC	DFS	Median	All	0.704	0.542	.001	65	view →
MESO	OS	Tertile	All	0.580	0.318	.006	56	view →
LIHC	OS	Median	All	0.777	0.599	<.001	40	view →
COAD	OS	Tertile	II,III,IV	0.908	0.677	<.001	26	view →
BLCA	OS	Tertile	All	0.784	0.628	.005	24	view →
LGG	OS	Tertile	All	0.721	0.842	.003	23	view →
ACC	DFS	Quartile	III,IV	0.562	0.063	.001	19	view →
PRAD	DFS	Tertile	All	0.928	0.829	.004	18	view →
SCLC	OS	Tertile	IV	0.247	0.735	.029	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SMIM14–HNSC (OS)

Open the HNSC breakdown →