SMIM10L2A

Across TCGA patient cohorts, SMIM10L2A mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMIM10L2A-associated genes across cancer lineages are MIR5191, OR2M4, and MAGEB10. Each is linked with SMIM10L2A in more than 1 cancer types. Because this analysis shows association rather than direction, both SMIM10L2A-to-partner and partner-to-SMIM10L2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5191 grouped by SMIM10L2A-low versus SMIM10L2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM10L2A→partner) and Y-score (partner→SMIM10L2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR5191 →	+0.357	+4.226	<.001	.008	3	1
UCEC	OR2M4 →	+0.121	+4.561	.009	<.001	3	1
UCEC	MAGEB10 →	+0.208	+3.741	<.001	.003	3	1
UCEC	EIF1AY →	+0.038	+3.789	<.001	.002	3	1
UCEC	RNU6-1292P →	+0.394	+4.453	<.001	.006	3	1
UCEC	RPS29P31 →	+0.476	+4.715	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MIR5191 by SMIM10L2A expression — UCEC

Explore this box plot interactively →