SMIM10L2A

Across TCGA pan-cancer cohorts, SMIM10L2A RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SMIM10L2A data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher SMIM10L2A RNA is associated with better overall survival. In most high-consensus cancer types, elevated SMIM10L2A expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRC show a favorable association.

UVM, KIRC, and MESO are the cancer types where SMIM10L2A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.831	0.393	<.001	151	view →
KIRC	DFS	Tertile	All	0.722	0.516	<.001	128	view →
MESO	OS	Quartile	All	0.674	0.345	.001	66	view →
KIRP	OS	Tertile	II,III,IV	0.881	0.498	<.001	56	view →
ACC	OS	Quartile	III,IV	1.000	0.276	.002	52	view →
UCEC	DFS	Tertile	II,III,IV	0.404	0.772	.003	52	view →
READ	OS	Median	IV	0.913	0.491	.001	47	view →
THCA	OS	Median	II,III,IV	1.000	0.544	.002	29	view →
COAD	OS	Median	All	0.820	0.913	.008	27	view →
LUSC	OS	Tertile	All	0.840	0.720	.002	22	view →
LIHC	DFS	Median	III,IV	0.593	0.219	.001	20	view →
ESCA	OS	Tertile	All	1.000	0.516	.018	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SMIM10L2A–UVM (OS)

Open the UVM breakdown →