SMCO2

Across TCGA patient cohorts, SMCO2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMCO2-associated genes across cancer lineages are Ku80, MEK1, and p70-S6K_pT389. Each is linked with SMCO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMCO2-to-partner and partner-to-SMCO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by SMCO2-low versus SMCO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMCO2→partner) and Y-score (partner→SMCO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.275	+2.183	.026	.035	3	1
UCEC	MEK1 →	+0.404	+3.000	.035	.036	3	1
UCEC	p70-S6K_pT389 →	-0.279	-3.321	.005	.010	3	1
UCEC	Annexin-1 →	+0.925	+3.321	<.001	.010	3	1
UCEC	Rictor_pT1135 →	-0.124	-3.000	.020	.036	3	1
UCEC	TIGAR →	+0.240	+3.348	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Ku80 by SMCO2 expression — UCEC

Explore this box plot interactively →