SMCO2

Across TCGA pan-cancer cohorts, SMCO2 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of SMCO2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SMCO2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SMCO2 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where SMCO2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMCO2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.716	<.001	12	view →
BLCA	All	III,IV	+0.665	<.001	11	view →
COAD	Female	II,III,IV	+0.320	<.001	10	view →
LUSC	Male	All	+0.989	<.001	9	view →
LUAD	All	II,III,IV	+0.563	<.001	8	view →
BRCA	All	II,III,IV	+0.487	<.001	8	view →
KIRC	All	All	+0.170	<.001	7	view →
LIHC	All	All	+0.163	<.001	7	view →
STAD	All	III,IV	+0.451	.016	6	view →
THCA	All	All	+0.130	<.001	6	view →
CHOL	All	All	+1.350	<.001	3	view →
KICH	Female	All	−0.145	.002	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

SMCO2–HNSC

Open the HNSC breakdown →