SMCO2

Across TCGA pan-cancer cohorts, SMCO2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SMCO2 data layer compared with 2 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher SMCO2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SMCO2 expression acts as an unfavorable survival marker, although some lineages such as COAD and ESCA show a favorable association.

MESO, PAAD, and UVM are the cancer types where SMCO2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.408	0.662	<.001	120	view →
PAAD	OS	Median	All	0.517	0.711	<.001	78	view →
UVM	OS	Tertile	II,III,IV	0.277	0.658	.001	57	view →
LGG	OS	Median	All	0.741	0.870	<.001	53	view →
COAD	DFS	Median	All	0.597	0.413	.008	43	view →
LIHC	DFS	Tertile	All	0.206	0.433	<.001	35	view →
LUAD	DFS	Tertile	All	0.223	0.412	.002	27	view →
ESCA	DFS	Tertile	III,IV	0.506	0.275	.013	24	view →
SKCM	OS	Tertile	IV	0.803	0.303	<.001	24	view →
SARC	DFS	Median	All	0.406	0.613	<.001	16	view →
ACC	OS	Median	II,III,IV	0.381	0.783	.003	15	view →
UCS	DFS	Tertile	IV	0.855	0.381	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SMCO2–MESO (OS)

Open the MESO breakdown →