SMCO2

Across TCGA cell cohorts, SMCO2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,169 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SMCO2-associated GO terms across cancer lineages are Cytoplasmic pattern recognition receptor signaling pathway, Positive regulation of plasma membrane repair, and Regulation of integrin-mediated signaling pathway. Each is linked with SMCO2 in more than 10 cancer types. Because this analysis shows association rather than direction, both SMCO2-to-partner and partner-to-SMCO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasmic pattern recognition receptor signaling pathway grouped by SMCO2-low versus SMCO2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMCO2→partner) and Y-score (partner→SMCO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Cytoplasmic pattern recognition receptor signaling pathway →	+0.071	+0.723	<.001	<.001	3	11
BONE	Positive regulation of plasma membrane repair →	+0.271	+0.373	<.001	.007	3	10
BLOOD_Lymphoma	Regulation of integrin-mediated signaling pathway →	+0.195	+0.617	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Positive regulation of cellular extravasation →	+0.225	+0.557	.003	.001	2	10
UPPER_AERODIGESTIVE_TRACT	Response to tumor necrosis factor →	+0.085	+0.594	<.001	<.001	3	9
BREAST	Regulation of protein processing →	+0.116	+0.453	.006	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,169 associations by consensus.

Cytoplasmic pattern recognition receptor signaling pathway by SMCO2 expression — PANCREAS

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