SMCO2

Across TCGA cell cohorts, SMCO2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMCO2-associated genes across cancer lineages are COX6A2, OR7A17, and CCER1. Each is linked with SMCO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMCO2-to-partner and partner-to-SMCO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX6A2 grouped by SMCO2-low versus SMCO2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMCO2→partner) and Y-score (partner→SMCO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COX6A2 →	+0.136	+6.022	<.001	.001	3	1
LARGE_INTESTINE	OR7A17 →	+0.019	+5.415	<.001	.004	3	1
LARGE_INTESTINE	CCER1 →	+0.019	+4.977	<.001	.007	3	1
LARGE_INTESTINE	KRT25 →	+0.013	+5.415	<.001	.004	3	1
LARGE_INTESTINE	OR10C1 →	+0.022	+5.415	<.001	.004	3	1
LUNG_SCLC	USP17L11 →	+0.013	+4.523	.009	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

COX6A2 by SMCO2 expression — LARGE_INTESTINE

Explore this box plot interactively →