SMAD9-IT1

Across TCGA patient cohorts, SMAD9-IT1 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,987 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SMAD9-IT1-associated proteins across cancer lineages are SORBS3, SEPTIN4, and CAVIN1. Each is linked with SMAD9-IT1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SMAD9-IT1-to-partner and partner-to-SMAD9-IT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMAD9-IT1 versus SORBS3 in CCRCC, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD9-IT1→partner) and Y-score (partner→SMAD9-IT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SORBS3 →	+0.387	+0.833	<.001	<.001	3	5
PDAC	SEPTIN4 →	+0.545	+0.336	<.001	.004	3	5
BRCA	CAVIN1 →	+0.640	+0.406	<.001	<.001	3	5
BRCA	EHD2 →	+0.694	+0.351	<.001	.001	3	5
BRCA	CNRIP1 →	+0.743	+0.492	<.001	<.001	3	5
BRCA	FHL1 →	+0.913	+0.398	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,987 associations by consensus.

SMAD9-IT1 vs SORBS3 — CCRCC

Explore this scatter interactively →