SMAD9-IT1

Across TCGA pan-cancer cohorts, SMAD9-IT1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SMAD9-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SMAD9-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types SMAD9-IT1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUSC are the cancer types where SMAD9-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMAD9-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.687	<.001	11	view →
KICH	Female	II,III,IV	−0.498	<.001	10	view →
LUSC	Female	All	−0.727	<.001	8	view →
BLCA	Male	All	−0.572	.001	8	view →
LUAD	Female	II,III,IV	−0.877	<.001	7	view →
BRCA	All	III,IV	−0.528	<.001	6	view →
KIRC	Female	All	+0.429	<.001	6	view →
READ	All	II,III,IV	−0.500	.003	5	view →
UCEC	All	IV	−0.345	.001	4	view →
LIHC	All	All	+0.045	.012	4	view →
COAD	All	III,IV	−0.390	.014	1	view →
KIRP	Male	All	−0.236	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SMAD9-IT1–THCA

Open the THCA breakdown →