SMAD9-IT1

Across TCGA pan-cancer cohorts, SMAD9-IT1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated SMAD9-IT1 data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher SMAD9-IT1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SMAD9-IT1 expression acts as an unfavorable survival marker, although some lineages such as LGG and UCS show a favorable association.

LGG, UCS, and ACC are the cancer types where SMAD9-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.519	0.362	<.001	37	view →
UCS	DFS	Median	IV	0.952	0.367	.001	32	view →
ACC	DFS	Tertile	IV	0.107	0.526	.007	30	view →
DLBC	OS	Quartile	All	0.455	0.842	.001	22	view →
STAD	OS	Quartile	IV	0.661	0.291	.021	16	view →
LAML	DFS	Quartile	All	0.527	0.276	.010	16	view →
GBM	OS	Tertile	All	0.565	0.280	.013	15	view →
THCA	OS	Quartile	All	0.982	1.000	.012	9	view →
ESCA	OS	Median	III,IV	0.546	0.320	.024	9	view →
LUSC	DFS	Tertile	II,III,IV	0.206	0.447	.014	6	view →
KICH	OS	Median	All	1.000	0.924	.011	4	view →
READ	DFS	Median	II,III,IV	0.837	0.750	.040	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

SMAD9-IT1–LGG (OS)

Open the LGG breakdown →