SMAD7

Across TCGA patient cohorts, SMAD7 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,683 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SMAD7-associated proteins across cancer lineages are VCL_S346, DDX21_S121, and DPYSL3. Each is linked with SMAD7 in more than 6 cancer types. Because this analysis shows association rather than direction, both SMAD7-to-partner and partner-to-SMAD7 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMAD7 versus VCL_S346 in COAD, with a Pearson correlation of 0.45.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD7→partner) and Y-score (partner→SMAD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	VCL_S346 →	+0.563	+0.669	<.001	<.001	3	7
BRCA	DDX21_S121 →	-0.796	-0.496	.001	.003	3	7
OV	DPYSL3 →	+0.509	+0.647	.002	.002	3	7
COAD	FMNL3 →	+0.408	+0.435	<.001	.001	3	7
OV	MMP2 →	+0.785	+1.009	<.001	<.001	3	7
OV	ILK →	+0.406	+0.936	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,683 associations by consensus.

SMAD7 vs VCL_S346 — COAD

Explore this scatter interactively →