SMAD7

Across TCGA patient cohorts, SMAD7 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMAD7-associated genes across cancer lineages are 14-3-3_beta, eEF2, and eIF4E. Each is linked with SMAD7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMAD7-to-partner and partner-to-SMAD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SMAD7-low versus SMAD7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD7→partner) and Y-score (partner→SMAD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.140	-3.295	.001	.009	3	1
UCEC	eEF2 →	+0.649	+3.459	<.001	.005	3	1
UCEC	eIF4E →	+0.248	+3.459	.009	.005	3	1
UCEC	ERK2 →	+0.267	+2.000	.002	.032	3	1
UCEC	GATA6 →	-0.240	-2.693	<.001	.006	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.469	+1.884	.014	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

14-3-3_beta by SMAD7 expression — UCEC

Explore this box plot interactively →