SMAD7

Across TCGA cell cohorts, SMAD7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,527 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SMAD7-associated GO terms across cancer lineages are Negative regulation of chondrocyte proliferation, Regulation of T-helper 17 cell differentiation, and Cardiac chamber morphogenesis. Each is linked with SMAD7 in more than 15 cancer types. Because this analysis shows association rather than direction, both SMAD7-to-partner and partner-to-SMAD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chondrocyte proliferation grouped by SMAD7-low versus SMAD7-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD7→partner) and Y-score (partner→SMAD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of chondrocyte proliferation →	+1.393	+2.015	<.001	<.001	3	16
OESOPHAGUS	Regulation of T-helper 17 cell differentiation →	+0.136	+1.516	<.001	<.001	3	15
KIDNEY	Cardiac chamber morphogenesis →	+0.142	+1.234	<.001	.002	3	14
BONE	Negative regulation of activin receptor signaling pathway →	+0.160	+2.003	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of ventricular cardiac muscle cell membrane depolarization →	+1.313	+1.264	<.001	<.001	3	14
BONE	SMAD protein signal transduction →	+0.175	+1.785	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,527 associations by consensus.

Negative regulation of chondrocyte proliferation by SMAD7 expression — LARGE_INTESTINE

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