SMAD5

Across TCGA patient cohorts, SMAD5 mutation is significantly associated with the RNA expression of many other genes, with 4,687 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMAD5-associated genes across cancer lineages are LINC01849, RNU6-1148P, and LINC02559. Each is linked with SMAD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMAD5-to-partner and partner-to-SMAD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01849 grouped by SMAD5-low versus SMAD5-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD5→partner) and Y-score (partner→SMAD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	LINC01849 →	+0.150	+5.653	<.001	.003	3	2
SKCM	RNU6-1148P →	+0.328	+7.816	<.001	.008	3	2
CESC	LINC02559 →	+1.058	+4.757	<.001	.004	3	2
UCEC	LINC02438 →	+0.644	+2.536	<.001	<.001	3	2
UCEC	RN7SL134P →	+0.092	+2.125	<.001	<.001	3	2
LIHC	MIR3666 →	+0.325	+5.268	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,687 associations by consensus.

LINC01849 by SMAD5 expression — READ

Explore this box plot interactively →