SMAD5

Across TCGA pan-cancer cohorts, SMAD5 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SMAD5’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SMAD5 RNA is repressed in tumor relative to normal tissue. In most cancer types SMAD5 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, LIHC, and COAD are the cancer types where SMAD5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMAD5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.621	<.001	9	view →
LIHC	All	II,III,IV	+0.928	<.001	7	view →
COAD	Male	All	+0.552	<.001	6	view →
HNSC	All	II,III,IV	+0.371	.008	6	view →
CHOL	Male	All	+2.431	<.001	3	view →
UCEC	All	All	−0.966	<.001	2	view →
KICH	All	All	−0.685	.001	2	view →
KIRP	All	IV	+0.652	.033	2	view →
LUAD	All	All	+0.282	.002	2	view →
ESCA	All	All	+0.506	.037	1	view →
KIRC	All	All	+0.184	.037	1	view →
BRCA	Female	All	−0.163	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SMAD5–THCA

Open the THCA breakdown →