SMAD5

Across TCGA cell cohorts, SMAD5 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SMAD5-associated genes across cancer lineages are GJD2, OPALIN, and KRTAP5-4. Each is linked with SMAD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMAD5-to-partner and partner-to-SMAD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJD2 grouped by SMAD5-low versus SMAD5-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD5→partner) and Y-score (partner→SMAD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GJD2 →	+0.013	+5.209	<.001	.005	3	1
SKIN	OPALIN →	+0.072	+4.977	<.001	.007	3	1
SKIN	KRTAP5-4 →	+0.101	+4.977	<.001	.007	3	1
SKIN	OR8K3 →	+0.073	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GJD2 by SMAD5 expression — BLOOD_Lymphoma

Explore this box plot interactively →