SMAD4

Across TCGA patient cohorts, SMAD4 mutation is significantly associated with the RNA expression of many other genes, with 4,866 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMAD4-associated genes across cancer lineages are TMBIM6, AP1AR, and EI24. Each is linked with SMAD4 in more than 4 cancer types. Because this analysis shows association rather than direction, both SMAD4-to-partner and partner-to-SMAD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMBIM6 grouped by SMAD4-low versus SMAD4-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD4→partner) and Y-score (partner→SMAD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	TMBIM6 →	+0.355	+2.807	<.001	.002	3	5
UCEC	AP1AR →	+0.467	+2.337	.005	.003	3	5
UCEC	EI24 →	+0.440	+1.807	.001	.004	3	5
STAD	LIMA1 →	+0.700	+3.338	<.001	<.001	3	5
UCEC	BRI3BP →	+0.692	+3.654	<.001	<.001	3	4
UCEC	SVIP →	+0.631	+3.087	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,866 associations by consensus.

TMBIM6 by SMAD4 expression — STAD

Explore this box plot interactively →