SLK

Across TCGA cell cohorts, SLK mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLK-associated genes across cancer lineages are REG1B, TRIM49D2, and AVP. Each is linked with SLK in more than 1 cancer types. Because this analysis shows association rather than direction, both SLK-to-partner and partner-to-SLK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by SLK-low versus SLK-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLK→partner) and Y-score (partner→SLK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	REG1B →	+2.366	+2.518	<.001	.006	3	2
STOMACH	TRIM49D2 →	+0.040	+5.285	<.001	.003	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	CABP5 →	+0.012	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	DEFB129 →	+0.043	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	REG3G →	+0.040	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

REG1B by SLK expression — LARGE_INTESTINE

Explore this box plot interactively →