SLK

Across TCGA pan-cancer cohorts, SLK RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SLK’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SLK RNA is repressed in tumor relative to normal tissue. In most cancer types SLK is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, LIHC, and UCEC are the cancer types where SLK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.625	<.001	8	view →
LIHC	All	II,III,IV	+0.747	<.001	7	view →
UCEC	All	All	−1.326	<.001	6	view →
CHOL	All	All	+1.545	<.001	5	view →
KICH	All	All	−0.740	<.001	4	view →
BRCA	Female	All	−0.224	.002	4	view →
PAAD	All	All	+0.952	.011	2	view →
READ	Female	All	−0.742	.004	2	view →
COAD	Female	All	−0.575	.009	2	view →
LUAD	All	IV	+0.220	.024	2	view →
LUSC	Female	II,III,IV	−0.628	.049	1	view →
LUAD	Female	All	−0.335	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SLK–THCA

Open the THCA breakdown →