SLITRK3

Across TCGA cell cohorts, SLITRK3 mutation is significantly associated with the RNA expression of many other genes, with 165 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLITRK3-associated genes across cancer lineages are COPS5, DNMT3B, and VWC2. Each is linked with SLITRK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLITRK3-to-partner and partner-to-SLITRK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPS5 grouped by SLITRK3-low versus SLITRK3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLITRK3→partner) and Y-score (partner→SLITRK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	COPS5 →	+0.540	+2.115	.001	.005	3	2
LUNG_NSCLC_LUAD	DNMT3B →	+0.718	+2.358	.001	.001	3	2
BLOOD_Leukemia	VWC2 →	+0.423	+4.551	<.001	.004	3	2
LARGE_INTESTINE	MAK16 →	+0.947	+3.067	<.001	.009	3	2
KIDNEY	H2AC1 →	+0.093	+5.000	<.001	.005	3	1
KIDNEY	ODF4 →	+0.030	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 165 associations by consensus.

COPS5 by SLITRK3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →