SLITRK3

Across TCGA pan-cancer cohorts, SLITRK3 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated SLITRK3 data layer compared with 13 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher SLITRK3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SLITRK3 expression acts as an unfavorable survival marker, although some lineages such as ESCA and UCS show a favorable association.

MESO, KICH, and BLCA are the cancer types where SLITRK3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	II,III,IV	0.275	0.524	<.001	108	view →
KICH	OS	Tertile	II,III,IV	0.279	0.878	<.001	72	view →
BLCA	DFS	Tertile	II,III,IV	0.252	0.464	.001	60	view →
KIRP	DFS	Tertile	All	0.838	0.944	<.001	42	view →
OV	DFS	Median	All	0.492	0.584	.010	28	view →
CHOL	OS	Tertile	II,III,IV	0.024	0.601	.025	27	view →
ESCA	OS	Tertile	All	0.635	0.481	.020	23	view →
UVM	DFS	Tertile	II,III,IV	0.390	0.611	.030	11	view →
UCS	DFS	Quartile	III,IV	0.649	0.114	.029	10	view →
ACC	OS	Quartile	All	0.423	0.844	<.001	10	view →
SKCM	OS	Quartile	II,III,IV	0.285	0.472	.012	7	view →
COAD	DFS	Quartile	All	0.719	0.853	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

SLITRK3–MESO (OS)

Open the MESO breakdown →