SLIRP

Across TCGA patient cohorts, SLIRP mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLIRP-associated genes across cancer lineages are MIR3142, LONRF2P4, and PPP1R26P2. Each is linked with SLIRP in more than 1 cancer types. Because this analysis shows association rather than direction, both SLIRP-to-partner and partner-to-SLIRP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3142 grouped by SLIRP-low versus SLIRP-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLIRP→partner) and Y-score (partner→SLIRP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR3142 →	+0.288	+7.640	<.001	.009	3	2
COAD	LONRF2P4 →	+0.089	+7.741	<.001	.009	3	1
COAD	PPP1R26P2 →	+0.014	+7.741	<.001	.009	3	1
COAD	MIR6868 →	+0.567	+7.741	<.001	.009	3	1
UCEC	RNA5SP161 →	+1.585	+3.265	<.001	.005	3	1
UCEC	RNA5SP248 →	+0.528	+3.656	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

MIR3142 by SLIRP expression — BLCA

Explore this box plot interactively →