SLIRP

Across TCGA pan-cancer cohorts, SLIRP RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated SLIRP data layer compared with 1 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SLIRP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SLIRP expression acts as an unfavorable survival marker, although some lineages such as LUSC and THCA show a favorable association.

UVM, KICH, and HNSC are the cancer types where SLIRP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.395	0.883	<.001	156	view →
KICH	OS	Median	II,III,IV	0.628	1.000	<.001	106	view →
HNSC	DFS	Median	All	0.633	0.751	<.001	98	view →
LUAD	DFS	Tertile	II,III,IV	0.299	0.681	<.001	91	view →
ACC	DFS	Median	All	0.264	0.643	<.001	83	view →
UCS	DFS	Median	IV	0.367	0.952	.001	82	view →
LUSC	OS	Tertile	All	0.758	0.582	<.001	37	view →
UCEC	DFS	Quartile	III,IV	0.654	0.897	.004	36	view →
COAD	OS	Median	IV	0.438	0.827	.003	22	view →
ESCA	DFS	Tertile	All	0.203	0.407	.008	21	view →
SCLC	DFS	Quartile	III,IV	0.260	0.604	.015	18	view →
PRAD	DFS	Tertile	All	0.840	0.942	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

SLIRP–UVM (OS)

Open the UVM breakdown →