SLIRP

Across TCGA pan-cancer cohorts, SLIRP RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SLIRP’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where SLIRP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLIRP is over-expressed in tumor.

LIHC, HNSC, and BLCA are the cancer types where SLIRP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLIRP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+0.903	<.001	9	view →
HNSC	Male	All	+0.451	<.001	9	view →
BLCA	All	All	+0.505	<.001	8	view →
LUSC	All	II,III,IV	+0.783	<.001	7	view →
LUAD	All	II,III,IV	+0.490	<.001	7	view →
UCEC	All	II,III,IV	+1.000	<.001	6	view →
BRCA	All	III,IV	+0.444	<.001	6	view →
CHOL	All	All	+0.786	.001	5	view →
COAD	Female	II,III,IV	+0.425	<.001	4	view →
STAD	All	IV	+1.013	.027	2	view →
ESCA	All	All	+0.856	.001	2	view →
PRAD	All	All	+0.294	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SLIRP–LIHC

Open the LIHC breakdown →