SLIRP

Across TCGA cell cohorts, SLIRP RNA expression is significantly associated with the go_rna of many other GO terms, with 4,153 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible SLIRP-associated GO terms across cancer lineages are Regulation of mitochondrial gene expression, Mitochondrial gene expression, and tRNA processing. Each is linked with SLIRP in more than 17 cancer types. Because this analysis shows association rather than direction, both SLIRP-to-partner and partner-to-SLIRP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitochondrial gene expression grouped by SLIRP-low versus SLIRP-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLIRP→partner) and Y-score (partner→SLIRP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of mitochondrial gene expression →	+0.120	+0.782	.001	.003	3	18
UPPER_AERODIGESTIVE_TRACT	Mitochondrial gene expression →	+0.090	+1.274	<.001	<.001	3	18
BONE	tRNA processing →	+0.064	+0.823	.002	.002	3	18
LUNG_NSCLC_LUSC	Mitochondrial tRNA processing →	+0.112	+0.624	.009	.005	3	17
LUNG_NSCLC_LUSC	Mitochondrial translation →	+0.094	+0.622	.001	.007	3	17
UPPER_AERODIGESTIVE_TRACT	Oxidative RNA demethylation →	+0.140	+1.575	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,153 associations by consensus.

Regulation of mitochondrial gene expression by SLIRP expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →