SLFN5

Across TCGA patient cohorts, SLFN5 mutation is significantly associated with the RNA expression of many other genes, with 1,873 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLFN5-associated genes across cancer lineages are LINC02706, LINC02559, and ADAM20P3. Each is linked with SLFN5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLFN5-to-partner and partner-to-SLFN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02706 grouped by SLFN5-low versus SLFN5-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN5→partner) and Y-score (partner→SLFN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LINC02706 →	+0.059	+5.048	<.001	.002	3	2
CESC	LINC02559 →	+1.329	+5.342	<.001	.002	3	2
CESC	ADAM20P3 →	+0.042	+5.345	<.001	.001	3	2
CESC	RN7SL134P →	+0.198	+4.874	<.001	.002	3	2
COAD	MIR5190 →	+0.648	+4.080	<.001	<.001	3	2
BRCA	RNU6-1127P →	+0.431	+5.195	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,873 associations by consensus.

LINC02706 by SLFN5 expression — BLCA

Explore this box plot interactively →