SLFN5

Across TCGA pan-cancer cohorts, SLFN5 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SLFN5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SLFN5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLFN5 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KIRP, HNSC, and KIRC are the cancer types where SLFN5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLFN5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+1.446	<.001	11	view →
HNSC	All	III,IV	+1.258	<.001	10	view →
KIRC	Male	All	+1.051	<.001	9	view →
KICH	Female	All	−1.219	<.001	7	view →
BRCA	All	III,IV	−1.026	<.001	6	view →
THCA	All	III,IV	+0.652	.003	6	view →
CHOL	All	All	+2.231	<.001	5	view →
ESCA	Male	All	+1.384	.006	4	view →
STAD	All	All	+0.834	.001	4	view →
LUSC	Male	All	−0.382	.021	4	view →
BLCA	Female	All	+0.764	.029	3	view →
LIHC	Female	All	+0.582	.012	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SLFN5–KIRP

Open the KIRP breakdown →