SLCO5A1

Across TCGA cell cohorts, SLCO5A1 mutation is significantly associated with the RNA expression of many other genes, with 352 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLCO5A1-associated genes across cancer lineages are PTH2R, SLC25A28, and DEUP1. Each is linked with SLCO5A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLCO5A1-to-partner and partner-to-SLCO5A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTH2R grouped by SLCO5A1-low versus SLCO5A1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO5A1→partner) and Y-score (partner→SLCO5A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PTH2R →	+1.000	+2.546	<.001	.002	3	2
LARGE_INTESTINE	SLC25A28 →	+0.526	+3.067	<.001	.009	3	2
LARGE_INTESTINE	DEUP1 →	+0.258	+3.055	<.001	.001	3	2
BREAST	IL3 →	+0.011	+3.781	<.001	.009	3	2
LUNG_NSCLC_LUAD	TAAR8 →	+0.017	+4.662	<.001	.005	3	2
OESOPHAGUS	OR8B4 →	+0.036	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 352 associations by consensus.

PTH2R by SLCO5A1 expression — LARGE_INTESTINE

Explore this box plot interactively →