SLCO5A1

Across TCGA pan-cancer cohorts, SLCO5A1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SLCO5A1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SLCO5A1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLCO5A1 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

COAD, LUAD, and KIRP are the cancer types where SLCO5A1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLCO5A1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+0.978	<.001	10	view →
LUAD	Female	II,III,IV	+1.132	<.001	9	view →
KIRP	All	II,III,IV	+0.458	<.001	9	view →
KIRC	All	II,III,IV	+0.228	<.001	7	view →
UCEC	All	All	+0.967	<.001	6	view →
LIHC	Male	II,III,IV	+0.148	.003	6	view →
ESCA	Female	All	+0.396	.006	4	view →
BRCA	Female	II,III,IV	+0.263	<.001	4	view →
LUSC	All	All	+0.451	<.001	3	view →
CHOL	Male	All	+0.329	<.001	2	view →
HNSC	Male	All	−0.700	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SLCO5A1–COAD

Open the COAD breakdown →