SLCO1B3

Across TCGA patient cohorts, SLCO1B3 mutation is significantly associated with the RNA expression of many other genes, with 5,619 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLCO1B3-associated genes across cancer lineages are RNA5SP412, DIABLO, and MED19. Each is linked with SLCO1B3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLCO1B3-to-partner and partner-to-SLCO1B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by SLCO1B3-low versus SLCO1B3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO1B3→partner) and Y-score (partner→SLCO1B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.469	+1.765	<.001	.001	3	4
UCEC	DIABLO →	+0.380	+1.856	.001	.002	3	4
UCEC	MED19 →	+0.320	+1.676	.001	.001	3	4
UCEC	TAF9 →	+0.639	+2.485	<.001	<.001	3	3
HNSC	MIR4716 →	+0.134	+3.936	<.001	.009	3	3
HNSC	RNASEH1P1 →	+0.478	+2.506	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,619 associations by consensus.

RNA5SP412 by SLCO1B3 expression — UCEC

Explore this box plot interactively →