SLCO1B3

Across TCGA pan-cancer cohorts, SLCO1B3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SLCO1B3 data layer compared with 12 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher SLCO1B3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLCO1B3 expression acts as an unfavorable survival marker, although some lineages such as THCA and ESCA show a favorable association.

BLCA, THCA, and HNSC are the cancer types where SLCO1B3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	All	0.555	0.669	.001	51	view →
THCA	OS	Median	All	0.985	0.907	.003	45	view →
HNSC	OS	Median	II,III,IV	0.694	0.786	.003	43	view →
ESCA	OS	Median	III,IV	0.715	0.423	.002	37	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	36	view →
LAML	DFS	Tertile	All	0.354	0.646	.005	24	view →
UCEC	DFS	Median	All	0.926	0.866	.005	20	view →
KIRP	DFS	Tertile	III,IV	0.520	0.691	.008	18	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	18	view →
LUAD	OS	Tertile	All	0.750	0.853	.004	18	view →
PAAD	DFS	Median	All	0.198	0.364	.003	17	view →
UCS	DFS	Tertile	IV	0.296	0.793	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SLCO1B3–BLCA (DFS)

Open the BLCA breakdown →