SLCO1B3-SLCO1B7

Across TCGA patient cohorts, SLCO1B3-SLCO1B7 mutation is significantly associated with the RNA expression of many other genes, with 2,059 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLCO1B3-SLCO1B7-associated genes across cancer lineages are SKA1, H2AZ1, and LRR1. Each is linked with SLCO1B3-SLCO1B7 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLCO1B3-SLCO1B7-to-partner and partner-to-SLCO1B3-SLCO1B7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by SLCO1B3-SLCO1B7-low versus SLCO1B3-SLCO1B7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO1B3-SLCO1B7→partner) and Y-score (partner→SLCO1B3-SLCO1B7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA1 →	+0.618	+3.480	<.001	.002	3	3
UCEC	H2AZ1 →	+0.616	+2.169	<.001	<.001	3	3
UCEC	LRR1 →	+0.567	+2.343	<.001	.003	3	3
UCEC	CHAF1A →	+0.678	+2.545	<.001	<.001	3	3
UCEC	POLR2G →	+0.440	+2.577	<.001	<.001	3	3
UCEC	STIP1 →	+0.409	+2.831	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,059 associations by consensus.

SKA1 by SLCO1B3-SLCO1B7 expression — UCEC

Explore this box plot interactively →