SLCO1B3-SLCO1B7

Across TCGA pan-cancer cohorts, SLCO1B3-SLCO1B7 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SLCO1B3-SLCO1B7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLCO1B3-SLCO1B7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLCO1B3-SLCO1B7 is over-expressed in tumor, although a few such as LIHC and BRCA show the opposite, repressed pattern.

HNSC, LIHC, and COAD are the cancer types where SLCO1B3-SLCO1B7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLCO1B3-SLCO1B7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.068	<.001	12	view →
LIHC	Female	All	−0.194	<.001	5	view →
COAD	All	All	+0.053	<.001	5	view →
LUAD	All	All	+0.050	.001	5	view →
BRCA	Female	All	−0.302	.010	4	view →
STAD	All	All	+0.050	.008	4	view →
LUSC	All	All	+0.021	.001	4	view →
CHOL	Female	All	−0.320	<.001	3	view →
PRAD	All	All	+0.086	.001	2	view →
THCA	Male	All	+0.015	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SLCO1B3-SLCO1B7–HNSC

Open the HNSC breakdown →