SLCO1B3-SLCO1B7

Across TCGA pan-cancer cohorts, SLCO1B3-SLCO1B7 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated SLCO1B3-SLCO1B7 data layer compared with 6 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SLCO1B3-SLCO1B7 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SLCO1B3-SLCO1B7 expression acts as an unfavorable survival marker, although some lineages such as LIHC and ESCA show a favorable association.

KIRC, OV, and LIHC are the cancer types where SLCO1B3-SLCO1B7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.227	0.663	<.001	138	view →
OV	DFS	Tertile	IV	0.251	0.519	<.001	72	view →
LIHC	DFS	Median	III,IV	0.489	0.265	.003	52	view →
ESCA	OS	Quartile	III,IV	0.644	0.248	.004	36	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	36	view →
MESO	OS	Tertile	All	0.018	0.559	<.001	36	view →
LAML	DFS	Tertile	All	0.194	0.576	.048	18	view →
UCS	OS	Tertile	All	0.201	0.583	.026	18	view →
LUAD	OS	Quartile	All	0.741	0.839	.013	14	view →
READ	OS	Tertile	II,III,IV	0.940	0.459	.005	14	view →
LGG	DFS	Tertile	All	0.926	0.801	.014	9	view →
CHOL	OS	Tertile	II,III,IV	0.323	0.741	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

SLCO1B3-SLCO1B7–KIRC (OS)

Open the KIRC breakdown →