SLCO1B3-SLCO1B7

Across TCGA patient cohorts, SLCO1B3-SLCO1B7 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLCO1B3-SLCO1B7-associated genes across cancer lineages are PCNA, Rad50, and ATM. Each is linked with SLCO1B3-SLCO1B7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLCO1B3-SLCO1B7-to-partner and partner-to-SLCO1B3-SLCO1B7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SLCO1B3-SLCO1B7-low versus SLCO1B3-SLCO1B7-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO1B3-SLCO1B7→partner) and Y-score (partner→SLCO1B3-SLCO1B7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PCNA →	+0.308	+3.169	.030	.019	3	2
UCEC	Rad50 →	-0.197	-1.502	.027	.030	3	2
UCEC	ATM →	-0.390	-1.847	.019	.008	3	2
LUSC	GSK-3a-b_pS21_S9 →	+0.487	+3.179	.016	.010	3	1
UCEC	JNK2 →	+0.199	+1.502	.006	.030	3	1
UCEC	MEK1 →	+0.436	+3.700	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

PCNA by SLCO1B3-SLCO1B7 expression — STAD

Explore this box plot interactively →