SLC7A8

Across TCGA cell cohorts, SLC7A8 mutation is significantly associated with the mutation status of many other genes, with 1,651 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SLC7A8-associated genes across cancer lineages are PRRC2B, VCAN, and WDR91. Each is linked with SLC7A8 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLC7A8-to-partner and partner-to-SLC7A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRRC2B grouped by SLC7A8-low versus SLC7A8-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A8→partner) and Y-score (partner→SLC7A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRRC2B →	+3.053	+3.718	.006	.006	1	5
LARGE_INTESTINE	VCAN →	+1.559	+3.630	.002	.002	1	4
UPPER_AERODIGESTIVE_TRACT	WDR91 →	+5.392	+5.392	.004	.004	1	4
UPPER_AERODIGESTIVE_TRACT	BRD4 →	+5.392	+5.392	.004	.004	1	4
UPPER_AERODIGESTIVE_TRACT	BRSK1 →	+4.392	+4.954	.008	.008	1	4
LARGE_INTESTINE	USP34 →	+1.559	+3.630	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,651 associations by consensus.

PRRC2B by SLC7A8 expression — SKIN

Explore this box plot interactively →