SLC7A8

Across TCGA pan-cancer cohorts, SLC7A8 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SLC7A8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SLC7A8 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC7A8 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where SLC7A8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC7A8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−3.523	<.001	12	view →
HNSC	Female	IV	+2.666	<.001	12	view →
KIRP	All	II,III,IV	−3.829	<.001	11	view →
LUAD	Male	II,III,IV	−1.280	<.001	9	view →
KICH	All	II,III,IV	−2.153	<.001	7	view →
BRCA	All	III,IV	+1.187	<.001	6	view →
UCEC	All	All	−1.785	<.001	4	view →
ESCA	Male	All	−1.696	.003	4	view →
STAD	All	All	−0.999	.001	4	view →
COAD	Male	IV	+0.795	.013	4	view →
LIHC	Male	All	−1.040	<.001	3	view →
LUSC	Male	All	+0.776	.003	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SLC7A8–KIRC

Open the KIRC breakdown →