SLC6A16

Across TCGA patient cohorts, SLC6A16 mutation is significantly associated with the RNA expression of many other genes, with 915 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A16-associated genes across cancer lineages are FAM236A, RNU4-13P, and MRPS5P3. Each is linked with SLC6A16 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC6A16-to-partner and partner-to-SLC6A16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM236A grouped by SLC6A16-low versus SLC6A16-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A16→partner) and Y-score (partner→SLC6A16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FAM236A →	+0.044	+7.473	<.001	.007	3	2
BRCA	RNU4-13P →	+0.218	+6.038	<.001	.001	3	2
BRCA	MRPS5P3 →	+0.285	+5.844	<.001	<.001	3	2
READ	HIGD1AP10 →	+0.247	+3.965	.005	.006	3	2
READ	LHX5-AS1 →	+0.138	+4.462	<.001	.001	3	2
CESC	LINC01899 →	+0.046	+5.201	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 915 associations by consensus.

FAM236A by SLC6A16 expression — BRCA

Explore this box plot interactively →