SLC6A16

Across TCGA pan-cancer cohorts, SLC6A16 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SLC6A16 data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SLC6A16 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SLC6A16 expression acts as an unfavorable survival marker, although some lineages such as KIRP and UVM show a favorable association.

KIRP, UVM, and LGG are the cancer types where SLC6A16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.938	0.578	<.001	66	view →
UVM	OS	Tertile	All	0.671	0.325	.003	59	view →
LGG	DFS	Median	All	0.671	0.800	<.001	49	view →
READ	DFS	Quartile	All	0.532	0.831	.003	45	view →
HNSC	DFS	Median	All	0.771	0.648	.003	32	view →
LAML	DFS	Tertile	All	0.430	0.667	.002	28	view →
KIRC	OS	Quartile	All	0.541	0.791	.005	26	view →
COAD	OS	Tertile	III,IV	0.175	0.646	.010	21	view →
ESCA	OS	Tertile	II,III,IV	0.654	0.338	.010	17	view →
OV	DFS	Quartile	III,IV	0.307	0.419	.009	12	view →
PAAD	DFS	Quartile	All	0.474	0.274	.013	10	view →
UCS	DFS	Quartile	II,III,IV	0.481	0.087	.034	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SLC6A16–KIRP (DFS)

Open the KIRP breakdown →