SLC6A16

Across TCGA cell cohorts, SLC6A16 mutation is significantly associated with the RNA expression of many other genes, with 511 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC6A16-associated genes across cancer lineages are MDS2, NPHS2, and GP9. Each is linked with SLC6A16 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC6A16-to-partner and partner-to-SLC6A16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MDS2 grouped by SLC6A16-low versus SLC6A16-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A16→partner) and Y-score (partner→SLC6A16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MDS2 →	+0.120	+4.000	<.001	.008	3	1
UPPER_AERODIGESTIVE_TRACT	NPHS2 →	+0.013	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	GP9 →	+0.239	+4.736	<.001	.009	3	1
LUNG_NSCLC_LUAD	HSFY2 →	+0.027	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	HSFY1 →	+0.017	+5.813	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR6C75 →	+0.022	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 511 associations by consensus.

MDS2 by SLC6A16 expression — BONE

Explore this box plot interactively →