SLC6A11

Across TCGA patient cohorts, SLC6A11 mutation is significantly associated with the RNA expression of many other genes, with 3,907 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A11-associated genes across cancer lineages are DNM1P28, RNA5SP410, and OTX1. Each is linked with SLC6A11 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC6A11-to-partner and partner-to-SLC6A11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNM1P28 grouped by SLC6A11-low versus SLC6A11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A11→partner) and Y-score (partner→SLC6A11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DNM1P28 →	+0.026	+2.022	.001	.009	3	3
UCEC	RNA5SP410 →	+0.420	+1.587	<.001	.004	3	3
SKCM	OTX1 →	+0.644	+2.591	<.001	<.001	3	3
UCEC	ALDOA →	+0.404	+1.643	.003	.003	3	2
UCEC	HIRIP3 →	+0.406	+1.903	.001	<.001	3	2
UCEC	PANK1 →	+0.462	+2.147	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,907 associations by consensus.

DNM1P28 by SLC6A11 expression — SKCM

Explore this box plot interactively →