SLC5A8

Across TCGA patient cohorts, SLC5A8 mutation is significantly associated with the RNA expression of many other genes, with 4,654 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC5A8-associated genes across cancer lineages are KIF23, MYO19, and CHCHD3. Each is linked with SLC5A8 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLC5A8-to-partner and partner-to-SLC5A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF23 grouped by SLC5A8-low versus SLC5A8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC5A8→partner) and Y-score (partner→SLC5A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIF23 →	+0.739	+2.389	<.001	<.001	3	5
UCEC	MYO19 →	+0.503	+3.235	<.001	<.001	3	4
UCEC	CHCHD3 →	+0.454	+1.788	.002	.001	3	4
UCEC	ZWINT →	+0.773	+2.378	<.001	<.001	3	4
UCEC	SAE1 →	+0.589	+2.378	<.001	<.001	3	4
UCEC	ARHGAP11A →	+0.705	+2.389	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,654 associations by consensus.

KIF23 by SLC5A8 expression — UCEC

Explore this box plot interactively →